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Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that

Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics

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This monograph presents the latest results related to bio-mechanical systems and materials. The bio-mechanical systems with which his book is concerned are prostheses, implants, medical operation robots and muscular re-training systems. To characterize and design such systems, a multi-disciplinary approach is required which involves the classical disciplines of mechanical/materials engineering and biology and medicine. The challenge in such an approach is that views, concepts or even language are sometimes different from discipline to discipline and the interaction and communication of the scientists must be first developed and adjusted. Within the context of materials' science, the book covers the interaction of materials with mechanical systems, their description as a mechanical system  or their mechanical properties.

Health & Biological Sciences --- Biomedical Engineering --- Biomedical engineering. --- Biomedical materials. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Clinical engineering --- Medical engineering --- Materials --- Engineering. --- Biophysics. --- Biological physics. --- Biomaterials. --- Biomedical Engineering. --- Biophysics and Biological Physics. --- Bioengineering --- Biophysics --- Engineering --- Biomedical engineering --- Biocompatibility --- Prosthesis --- Biomedical Engineering and Bioengineering. --- Biological and Medical Physics, Biophysics. --- Bioartificial materials --- Hemocompatible materials --- Biological physics --- Biology --- Medical sciences --- Physics --- Biomaterials (Biomedical materials)

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Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.

Quadruplex nucleic acids --- Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- G-quadruplexes --- G-tetrads --- Guanine quadruplexes --- Tetraplex nucleic acids --- Chemistry. --- Bioorganic chemistry. --- Medical biochemistry. --- Nucleic acids. --- Biophysics. --- Biological physics. --- Bioorganic Chemistry. --- Nucleic Acid Chemistry. --- Medical Biochemistry. --- Biophysics and Biological Physics. --- Quadruplex nucleic acids. --- Nucleic acids --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Polynucleotides --- Biomolecules --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Composition --- Biological physics --- Physics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pathology

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Systems Biomechanics of the Cell attempts to outline systems biomechanics of the cell as an emergent and promising discipline. The new field owes conceptually to cell mechanics, organism-level systems biomechanics, and biology of biochemical systems. Its distinct methodology is to elucidate the structure and behavior of the cell by analyzing the unintuitive collective effects of elementary physical forces that interact within the heritable cellular framework. The problematics amenable to this approach includes the variety of cellular activities that involve the form and movement of the cell body and boundary (nucleus, centrosome, microtubules, cortex, and membrane). Among the elementary system effects in the biomechanics of the cell, instability of symmetry, emergent irreversibility, and multiperiodic dissipative motion can be noted. Research results from recent journal articles are placed in this unifying framework. It is suggested that the emergent discipline has the potential to expand the spectrum of questions asked about the cell, and to further clarify the physical nature of animate matter and motion.

Health & Biological Sciences --- Biomedical Engineering --- Cells --- Systems biology. --- Mechanical properties. --- Cell mechanics --- Cellular mechanics --- Engineering. --- Cell biology. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Biomedical Engineering. --- Cell Biology. --- Biophysics and Biological Physics. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Biomechanics --- Cytology. --- Biomedical Engineering and Bioengineering. --- Biological and Medical Physics, Biophysics. --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biological physics --- Medical sciences --- Physics

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Complex Systems are made up of numerous interacting sub-components. Non-linear interactions of these components or agents give rise to emergent behavior observable at the global scale. Agent-based modeling and simulation is a proven paradigm which has previously been used for effective computational modeling of complex systems in various domains. Because of its popular use across different scientific domains, research in agent-based modeling has primarily been vertical in nature. The goal of this book is to provide a single hands-on guide to developing cognitive agent-based models for the exploration of emergence across various types of complex systems. We present practical ideas and examples for researchers and practitioners for the building of agent-based models using a horizontal approach - applications are demonstrated in a number of exciting domains as diverse as wireless sensors networks, peer-to-peer networks, complex social systems, research networks and epidemiological HIV.

Artificial intelligence. --- Intelligent agents (Computer software). --- Programming languages (Electronic computers). --- Medicine --- Health & Biological Sciences --- Neurology --- Social systems --- Social sciences --- Mathematical models. --- Medicine. --- Neurosciences. --- Computer science. --- Mathematics. --- Biophysics. --- Biological physics. --- Cognitive psychology. --- Biomedicine. --- Computer Science, general. --- Mathematics, general. --- Cognitive Psychology. --- Biophysics and Biological Physics. --- Sociology --- System theory --- Consciousness. --- Biological and Medical Physics, Biophysics. --- Apperception --- Mind and body --- Perception --- Philosophy --- Psychology --- Spirit --- Self --- Math --- Science --- Informatics --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological physics --- Biology --- Physics --- Psychology, Cognitive --- Cognitive science